Abstract
As a consequence of multidrug resistance, clinicians are highly dependent on fluoroquinolones for treating the serious systemic infection typhoid fever. While reduced susceptibility to fluoroquinolones, which lessens clinical efficacy, is becoming ubiquitous, comprehensive resistance is exceptional. Here we report ofloxacin treatment failure in typhoidal patient infected with a novel, highly fluoroquinolone-resistant isolate of Salmonella enterica serovar Typhi. The isolation of this organism has serious implications for the long-term efficacy of ciprofloxacin and ofloxacin for typhoid treatment.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Amino Acid Sequence
-
Anti-Bacterial Agents / therapeutic use*
-
Azithromycin / therapeutic use
-
Bacterial Proteins / genetics*
-
DNA Gyrase / genetics*
-
Drug Resistance, Multiple, Bacterial / genetics
-
Fluoroquinolones / therapeutic use*
-
Humans
-
Male
-
Microbial Sensitivity Tests
-
Molecular Sequence Data
-
Mutation
-
Nepal
-
Ofloxacin / therapeutic use
-
Salmonella typhi / drug effects
-
Salmonella typhi / genetics*
-
Salmonella typhi / isolation & purification
-
Salmonella typhi / pathogenicity
-
Treatment Failure
-
Typhoid Fever / drug therapy*
-
Typhoid Fever / microbiology
Substances
-
Anti-Bacterial Agents
-
Bacterial Proteins
-
Fluoroquinolones
-
Azithromycin
-
Ofloxacin
-
DNA Gyrase