1-Methyl-4-phenylpyridinium (MPP+) does not exhibit paraquat-like immunoreactivity

P Houzé; O Chappey; H Gallons; J M Scherrmann

doi:10.1016/0378-4274(90)90238-h

1-Methyl-4-phenylpyridinium (MPP+) does not exhibit paraquat-like immunoreactivity

Toxicol Lett. 1990 Oct;53(3):339-42. doi: 10.1016/0378-4274(90)90238-h.

Authors

P Houzé¹, O Chappey, H Gallons, J M Scherrmann

Affiliation

¹ INSERM U26, Hôpital Fernand Widal, Paris, France.

PMID: 2237940
DOI: 10.1016/0378-4274(90)90238-h

Abstract

The structural analogy of paraquat with 1-methyl-4-phenylpyridinium (MPP+) has been implied in the aetiology of Parkinson's disease. The cross-reactivity of MPP+ to a specific antibody to paraquat was assessed by radioimmunoassay and was found to be very low. The results suggest that this polyclonal paraquat antibody does not mimic the MPP+ receptor.

MeSH terms

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / immunology
1-Methyl-4-phenylpyridinium / chemistry
1-Methyl-4-phenylpyridinium / immunology*
Antibodies / immunology
Cross Reactions
Humans
Molecular Conformation
Paraquat / chemistry
Paraquat / immunology*
Radioimmunoassay

Substances

Antibodies
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Paraquat
1-Methyl-4-phenylpyridinium