iPSCs to the rescue in Alzheimer's research

Se Hoon Choi; Rudolph E Tanzi

doi:10.1016/j.stem.2012.02.011

iPSCs to the rescue in Alzheimer's research

Cell Stem Cell. 2012 Mar 2;10(3):235-6. doi: 10.1016/j.stem.2012.02.011.

Authors

Se Hoon Choi¹, Rudolph E Tanzi

Affiliation

¹ Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

PMID: 22385650
DOI: 10.1016/j.stem.2012.02.011

Abstract

A crucial limitation to our understanding of Alzheimer's disease has been the inability to test hypotheses on live, patient-specific neurons. A recent study in Nature by Israel et al. (2012) reports that iPSC-derived neurons from AD patients recapitulate multiple aspects of disease pathology.

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