DNA-damage-induced differentiation in hematopoietic stem cells

Pankaj K Mandal; Derrick J Rossi

doi:10.1016/j.cell.2012.02.011

DNA-damage-induced differentiation in hematopoietic stem cells

Cell. 2012 Mar 2;148(5):847-8. doi: 10.1016/j.cell.2012.02.011.

Authors

Pankaj K Mandal¹, Derrick J Rossi

Affiliation

¹ Department of Stem Cell and Regenerative Biology, Harvard University, Immune Disease Institute, Children's Hospital Boston, Boston, MA 02116, USA.

PMID: 22385954
DOI: 10.1016/j.cell.2012.02.011

Abstract

Aging of hematopoietic stem cells (HSCs) is accompanied by diminished functional potential. Wang et al. now provide evidence for an HSC-specific differentiation checkpoint mediated by the transcription factor BATF, which limits self-renewal of HSCs in response to the accumulation of DNA damage.

Publication types

Comment

MeSH terms

Animals
Cell Cycle Checkpoints*
Cell Differentiation*
Cellular Senescence*
DNA Damage*
Hematopoietic Stem Cells / cytology*
Hematopoietic Stem Cells / metabolism*
Humans