Laparo-endoscopic single-site (LESS) renal surgery is steadily gaining momentum. LESS by itself is technically challenging, with a potentially increased procedural risk, and the presence of major vascular anomaly may increase the risk of intraoperative mishap. Here we present a case of left transperitoneal LESS radical nephrectomy that was successfully performed in the presence of double inferior vena cava with associated complex renal vascular anomalies. What is more important is to bring such an aberrant vascular anatomy to the attention of laparoscopic, especially LESS, surgeons.
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