Could age modify the effect of genetic variants in IL6 and TNF-α genes in multiple myeloma?

Alessandro Martino; Gabriele Buda; Valentina Maggini; Francesco Lapi; Antonella Lupia; Domenica Di Bello; Enrico Orciuolo; Sara Galimberti; Roberto Barale; Mario Petrini; Anna Maria Rossi

doi:10.1016/j.leukres.2012.02.009

Could age modify the effect of genetic variants in IL6 and TNF-α genes in multiple myeloma?

Leuk Res. 2012 May;36(5):594-7. doi: 10.1016/j.leukres.2012.02.009. Epub 2012 Mar 3.

Authors

Alessandro Martino¹, Gabriele Buda, Valentina Maggini, Francesco Lapi, Antonella Lupia, Domenica Di Bello, Enrico Orciuolo, Sara Galimberti, Roberto Barale, Mario Petrini, Anna Maria Rossi

Affiliation

¹ Department of Biology, Genetics division, University of Pisa, Italy. [email protected]

PMID: 22387051
DOI: 10.1016/j.leukres.2012.02.009

Abstract

Cytokines play a central role in multiple myeloma (MM) pathogenesis thus genetic variations within cytokines coding genes could influence MM susceptibility and therapy outcome. We investigated the impact of 8 SNPs in these genes in 202 MM cases and 235 controls also evaluating their impact on therapy outcome in a subset of 91 patients. Despite the overall negative findings, we found a significant age-modified effect of IL6 and TNF-α SNPs, on MM risk and therapy outcome, respectively. Therefore, this observation suggests that genetic variation in inflammation-related genes could be an important mediator of the complex interplay between ageing and cancer.

MeSH terms

Adult
Age Factors
Aged
Aged, 80 and over
Disease-Free Survival
Female
Genetic Variation*
Humans
Interleukin-6 / genetics*
Kaplan-Meier Estimate
Male
Middle Aged
Multiple Myeloma / drug therapy
Multiple Myeloma / genetics*
Multiple Myeloma / mortality
Polymorphism, Single Nucleotide*
Tumor Necrosis Factor-alpha / genetics*

Substances

IL6 protein, human
Interleukin-6
Tumor Necrosis Factor-alpha