Abstract
Chemical investigation of the methanolic extract of the rhizomes of Iris germanica L. (Iridaceae) afforded two new compounds; irigenin S (7) and iriside A (12), together with ten known compounds: stigmasterol (1), a-irone (2), γ-irone (3), 3-hydroxy-5-methoxyacetophenone (4), irilone (5), irisolidone (6), irigenin (8), stigmasterol-3-O-β-D-glucopyranoside (9), irilone 4'-O-β-D-glucopyranoside (10) and iridin (11). Their structures were established by UV, IR, 1D (¹H and ¹³C) and 2D (¹H-¹H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to mass spectroscopic data and comparison with literature data. The methanolic extract was evaluated for its antimicrobial activity. Both the methanolic extract and the isolated flavonoids were tested for their anti-inflammatory activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Bacteria / drug effects
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Edema / chemically induced
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Edema / drug therapy
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Egypt
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Formaldehyde
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Fungi / drug effects
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Iris Plant / chemistry*
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Isoflavones / chemistry
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Isoflavones / isolation & purification*
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Isoflavones / pharmacology
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Male
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Methanol / chemistry
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Microbial Sensitivity Tests
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Models, Chemical
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Molecular Structure
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification*
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Plant Extracts / pharmacology
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Random Allocation
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Rats
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Rhizome / chemistry*
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Solvents / chemistry
Substances
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Anti-Bacterial Agents
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Anti-Inflammatory Agents
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Antifungal Agents
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Isoflavones
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Plant Extracts
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Solvents
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irigenin S
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iriside A
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Formaldehyde
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Methanol