Abstract
In vitro testing of Aspergillus fumigatus susceptibility to echinocandins has always been a challenge. Using a simple and quick colorimetric method to analyze the activity of inhibitors of β-1,3-glucan synthesis, we found that the composition of the culture medium significantly influences glucan synthesis and consequently the antifungal properties of inhibitors of β-1,3-glucan synthesis when they are tested alone or in combination with chitin synthase inhibitors.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antifungal Agents / pharmacology*
-
Aspergillus fumigatus / drug effects*
-
Aspergillus fumigatus / metabolism*
-
Caspofungin
-
Culture Media / pharmacology*
-
Echinocandins / pharmacology
-
Glycosides / pharmacology
-
Lipopeptides
-
Miconazole / pharmacology
-
Microbial Sensitivity Tests
-
Triterpenes / pharmacology
-
beta-Glucans / metabolism*
Substances
-
Antifungal Agents
-
Culture Media
-
Echinocandins
-
Glycosides
-
Lipopeptides
-
Triterpenes
-
beta-Glucans
-
enfumafungin
-
Miconazole
-
beta-1,3-glucan
-
Caspofungin