Abstract
In this work we consider marketed drugs for Alzheimer disease (AD) including acetylcholinesterase inhibitors (AChE-Is) and antiglutamatergic treatment involving the N-methyl-d-aspartate (NMDA) receptor. We discuss medications and substances available for use as cognitive enhancers that are not approved for AD or cognitive impairment, and other neurotransmitter-related therapies in development or currently being researched. We also review putative therapies that aim to slow disease progression by mechanisms not directly related to amyloid or tau.
Publication types
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Historical Article
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alkaloids / therapeutic use
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Alzheimer Disease / diagnosis
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Alzheimer Disease / drug therapy*
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Amino Acids / therapeutic use
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Animals
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Cholinesterase Inhibitors / history
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Cholinesterase Inhibitors / therapeutic use*
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Dietary Supplements
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Disease Progression
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Docosahexaenoic Acids / therapeutic use
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Donepezil
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Drug Approval
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Galantamine / pharmacology
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Galantamine / therapeutic use
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Ginkgo biloba
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Half-Life
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History, 20th Century
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Humans
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Indans / pharmacology
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Indans / therapeutic use
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Memantine / pharmacology
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Memantine / therapeutic use
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Nootropic Agents / therapeutic use
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Phenylcarbamates / pharmacology
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Phenylcarbamates / therapeutic use
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Phytotherapy
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Piperidines / pharmacology
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Piperidines / therapeutic use
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Psychotropic Drugs / pharmacology
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Psychotropic Drugs / therapeutic use
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Receptors, AMPA / drug effects
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Receptors, N-Methyl-D-Aspartate / drug effects*
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Rivastigmine
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Sesquiterpenes / therapeutic use
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Vitamin B Complex / therapeutic use
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Vitamin E / therapeutic use
Substances
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Alkaloids
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Amino Acids
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Cholinesterase Inhibitors
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Indans
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Nootropic Agents
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Phenylcarbamates
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Piperidines
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Psychotropic Drugs
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Receptors, AMPA
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Receptors, N-Methyl-D-Aspartate
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Sesquiterpenes
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huperzine A
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Galantamine
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Vitamin B Complex
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Vitamin E
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Docosahexaenoic Acids
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cerebrolysin
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Donepezil
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Rivastigmine
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Memantine