A facile copper-catalyzed one-pot domino synthesis of 5,12-dihydroindolo[2,1-b]quinazolines

Org Lett. 2012 Mar 16;14(6):1420-3. doi: 10.1021/ol3001624. Epub 2012 Mar 6.

Abstract

A domino synthesis of 5,12-dihydroindolo[2,1-b]quinazoline derivatives via copper-catalyzed Ullmann-type intermolecular C-C and intramolecular C-N couplings is reported. Good yields of various 5,12-dihydroindolo[2,1-b]quinazoline derivatives were obtained. Reaction scopes, limitations, and the reaction mechanism are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Copper / chemistry*
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Iodides / chemistry*
  • Molecular Structure
  • Quinazolines / chemical synthesis*
  • Quinazolines / chemistry

Substances

  • Indoles
  • Iodides
  • Quinazolines
  • Copper
  • cuprous iodide