Initial sequence characterization of the rhabdoviruses of squamate reptiles, including a novel rhabdovirus from a caiman lizard (Dracaena guianensis)

Vet Microbiol. 2012 Aug 17;158(3-4):274-9. doi: 10.1016/j.vetmic.2012.02.020. Epub 2012 Feb 17.

Abstract

Rhabdoviruses infect a variety of hosts, including non-avian reptiles. Consensus PCR techniques were used to obtain partial RNA-dependent RNA polymerase gene sequence from five rhabdoviruses of South American lizards; Marco, Chaco, Timbo, Sena Madureira, and a rhabdovirus from a caiman lizard (Dracaena guianensis). The caiman lizard rhabdovirus formed inclusions in erythrocytes, which may be a route for infecting hematophagous insects. This is the first information on behavior of a rhabdovirus in squamates. We also obtained sequence from two rhabdoviruses of Australian lizards, confirming previous Charleville virus sequence and finding that, unlike a previous sequence report but in agreement with serologic reports, Almpiwar virus is clearly distinct from Charleville virus. Bayesian and maximum likelihood phylogenetic analysis revealed that most known rhabdoviruses of squamates cluster in the Almpiwar subgroup. The exception is Marco virus, which is found in the Hart Park group.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Australia
  • Erythrocytes / virology
  • Lizards / virology
  • Microscopy, Electron, Transmission
  • Molecular Sequence Data
  • Phylogeny
  • Polymerase Chain Reaction
  • Reptiles / virology*
  • Rhabdoviridae / classification
  • Rhabdoviridae / genetics*
  • Rhabdoviridae / isolation & purification
  • Rhabdoviridae / ultrastructure
  • Rhabdoviridae Infections / pathology
  • Rhabdoviridae Infections / virology*
  • South America

Associated data

  • GENBANK/JN882642
  • GENBANK/JN882643
  • GENBANK/JN882644
  • GENBANK/JN882645
  • GENBANK/JN882646
  • GENBANK/JN882647
  • GENBANK/JN882648