The measles virus N(TAIL)-XD complex: an illustrative example of fuzziness

Adv Exp Med Biol. 2012:725:126-41. doi: 10.1007/978-1-4614-0659-4_8.

Abstract

In this chapter, I focus on the biochemical and structural characterization of the complex between the intrinsically disordered C-terminal domain of the measles virus nucleoprotein (N(TAIL)) and the C-terminal X domain (XD) of the viral phosphoprotein (P). I summarize the main experimental data available so far pointing out the prevalently disordered nature of N(TAIL) even after complex formation and the role of the flexible C-terminal appendage in the binding reaction. I finally discuss the possible functional role of these residual disordered regions within the complex in terms of their ability to capture other regulatory, binding partners.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Measles virus / physiology*
  • Models, Molecular
  • Nucleocapsid Proteins
  • Nucleoproteins / chemistry*
  • Nucleoproteins / metabolism
  • Phosphoproteins / chemistry*
  • Phosphoproteins / metabolism
  • Protein Folding
  • Protein Structure, Tertiary
  • Viral Proteins / chemistry*
  • Viral Proteins / metabolism

Substances

  • Nucleocapsid Proteins
  • Nucleoproteins
  • Phosphoproteins
  • Viral Proteins
  • nucleoprotein, Measles virus