Effect of preoperative rescue concomitant FUN/XUN-based chemo-radiotherapy for neoadjuvant chemotherapy-refractory breast cancer

Céline Bourgier; Ismael Ghorbel; Steve Heymann; Manel Barhi; Chafika Mazouni; Abir Al Al Ghuzlan; Corinne Balleyguier; Hugo Marsiglia; Suzette Delaloge

doi:10.1016/j.radonc.2012.01.008

Effect of preoperative rescue concomitant FUN/XUN-based chemo-radiotherapy for neoadjuvant chemotherapy-refractory breast cancer

Radiother Oncol. 2012 May;103(2):151-4. doi: 10.1016/j.radonc.2012.01.008. Epub 2012 Mar 6.

Authors

Céline Bourgier¹, Ismael Ghorbel, Steve Heymann, Manel Barhi, Chafika Mazouni, Abir Al Al Ghuzlan, Corinne Balleyguier, Hugo Marsiglia, Suzette Delaloge

Affiliation

¹ Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France. [email protected]

PMID: 22402230
DOI: 10.1016/j.radonc.2012.01.008

Abstract

Even though tumor progression under neoadjuvant chemotherapy is uncommon, its locoregional management remains absolutely unclear. What is the best time for radical surgery or radiotherapy? "Rescue" chemo-radiotherapy could be a suitable radiosensitizing strategy to further reduce tumor progression and allow curative surgery while maintaining systemic therapy.

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Breast Neoplasms / mortality
Breast Neoplasms / pathology
Breast Neoplasms / therapy*
Chemoradiotherapy*
Female
Humans
Middle Aged
Neoadjuvant Therapy