Successful treatment of imported mucosal Leishmania infantum leishmaniasis with miltefosine after severe hypokalemia under meglumine antimoniate treatment

J Travel Med. 2012 Mar-Apr;19(2):124-6. doi: 10.1111/j.1708-8305.2011.00572.x. Epub 2011 Dec 8.

Abstract

Old World mucosal leishmaniasis is a rare but regularly reported disease in Southern Europe. We report the case of a 64-year-old woman who developed severe hypokalemia under meglumine antimoniate treatment and was successfully treated under second line therapy with miltefosine.

MeSH terms

  • Animals
  • Anti-Allergic Agents / therapeutic use
  • Antiprotozoal Agents / administration & dosage
  • Antiprotozoal Agents / adverse effects
  • Arrhythmias, Cardiac / diagnosis
  • Arrhythmias, Cardiac / etiology
  • Biopsy
  • Drug Administration Routes
  • Drug Substitution
  • Electrocardiography
  • Endemic Diseases*
  • Exanthema / chemically induced
  • Exanthema / therapy
  • Female
  • Greece
  • Humans
  • Hypokalemia* / blood
  • Hypokalemia* / chemically induced
  • Hypokalemia* / complications
  • Hypokalemia* / therapy
  • Insect Vectors*
  • Italy
  • Leishmania infantum* / drug effects
  • Leishmania infantum* / isolation & purification
  • Leishmaniasis, Visceral* / complications
  • Leishmaniasis, Visceral* / diagnosis
  • Leishmaniasis, Visceral* / drug therapy
  • Leishmaniasis, Visceral* / physiopathology
  • Leishmaniasis, Visceral* / transmission
  • Meglumine Antimoniate
  • Meglumine* / administration & dosage
  • Meglumine* / adverse effects
  • Middle Aged
  • Morocco
  • Mouth Mucosa / pathology
  • Oral Ulcer* / drug therapy
  • Oral Ulcer* / etiology
  • Oral Ulcer* / pathology
  • Oral Ulcer* / physiopathology
  • Organometallic Compounds* / administration & dosage
  • Organometallic Compounds* / adverse effects
  • Phosphorylcholine / administration & dosage
  • Phosphorylcholine / adverse effects
  • Phosphorylcholine / analogs & derivatives*
  • Potassium / blood
  • Potassium / therapeutic use
  • Psychodidae*
  • Spain
  • Travel*
  • Treatment Outcome

Substances

  • Anti-Allergic Agents
  • Antiprotozoal Agents
  • Organometallic Compounds
  • Phosphorylcholine
  • miltefosine
  • Meglumine
  • Meglumine Antimoniate
  • Potassium