Abstract
Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P. falciparum and low μM concentrations against T. cruzi.
Published by Elsevier Ltd.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiparasitic Agents / chemistry*
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Antiparasitic Agents / pharmacokinetics
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Antiparasitic Agents / pharmacology*
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Cations
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Chagas Disease / drug therapy
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Chlorocebus aethiops
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Humans
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Inhibitory Concentration 50
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Lipids / chemistry
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Lipids / pharmacokinetics
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Models, Biological
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Organophosphorus Compounds / chemistry
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Organophosphorus Compounds / pharmacokinetics
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Organophosphorus Compounds / pharmacology
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Plasmodium falciparum / drug effects*
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Trypanosoma cruzi / drug effects*
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Ubiquinone / analogs & derivatives
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Ubiquinone / chemistry
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Ubiquinone / pharmacokinetics
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Ubiquinone / pharmacology
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Vero Cells
Substances
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Antiparasitic Agents
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Cations
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Lipids
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Organophosphorus Compounds
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Ubiquinone
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mitoquinone