Abstract
VEGF is a pivotal pro-angiogenic growth factor and its dosage decisively impacts vascularization. We recently identified a CTCF-dependent chromatin insulator that critically restrains the transcriptional induction of VEGF and angiogenesis. We postulate that CTCF may exert enhancer blocking by mediating chromatin looping and/or RNA polymerase pausing at the VEGF locus.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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CCCTC-Binding Factor
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Chromatin / metabolism*
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Enhancer Elements, Genetic
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Histones / metabolism
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Human Umbilical Vein Endothelial Cells
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Humans
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Insulator Elements
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K562 Cells
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Neovascularization, Physiologic*
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RNA Polymerase II / metabolism
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Repressor Proteins / genetics
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Repressor Proteins / metabolism*
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Vascular Endothelial Growth Factor A / genetics
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Vascular Endothelial Growth Factor A / metabolism
Substances
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CCCTC-Binding Factor
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CTCF protein, human
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Chromatin
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Histones
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Repressor Proteins
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Vascular Endothelial Growth Factor A
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RNA Polymerase II