A novel conjugate of a cell-penetrating peptide and a ferrocenyl amino acid: a potential electrochemical sensor for living cells?

Dalton Trans. 2012 Jun 7;41(21):6396-8. doi: 10.1039/c2dt12211a. Epub 2012 Mar 14.

Abstract

The conjugation of a ferrocenyl amino acid to the cell-penetrating peptide hCT(9-32) does not impair its ability to efficiently translocate into cells. Furthermore, the bioconjugate does not induce any cytotoxicity, thus presenting a potential electrochemical sensor suitable for the detection of living cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry*
  • Amino Acids / metabolism*
  • Biosensing Techniques / methods*
  • Cell Survival
  • Cell-Penetrating Peptides / metabolism*
  • Electrochemistry
  • Ferrous Compounds / chemistry*
  • HeLa Cells
  • Humans
  • Metallocenes

Substances

  • Amino Acids
  • Cell-Penetrating Peptides
  • Ferrous Compounds
  • Metallocenes
  • ferrocene