Abstract
A convenient method for the copper(I)-catalyzed arylation of substituted imidazo[1,2-a]pyridine has been developed. This method is applicable to a variety of aryl electrophiles, including bromides, iodides, and triflates. It represents the first general process for C-3 arylation of substituted imidazo[1,2-a]pyridine by Cu(I) catalysis to construct various functionalized imidazo[1,2-a]pyridine core π-systems.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Combinatorial Chemistry Techniques
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Copper / chemistry*
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Hydrocarbons, Brominated / chemical synthesis
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Hydrocarbons, Brominated / chemistry*
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Hydrocarbons, Iodinated / chemical synthesis
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Hydrocarbons, Iodinated / chemistry*
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Imidazoles / chemical synthesis*
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Imidazoles / chemistry
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Mesylates / chemical synthesis
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Mesylates / chemistry*
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Molecular Structure
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Pyridines / chemical synthesis*
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Pyridines / chemistry
Substances
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Hydrocarbons, Brominated
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Hydrocarbons, Iodinated
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Imidazoles
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Mesylates
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Pyridines
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Copper