Spermine-like functions of N1, N12-bis(ethyl)spermine: stimulation of protein synthesis and cell growth and inhibition of gastric ulceration

Biochem Biophys Res Commun. 1990 Oct 30;172(2):715-20. doi: 10.1016/0006-291x(90)90733-4.

Abstract

The spermine analogue N1, N12-bis(ethyl)spermine (BESPM) could mimic the functions of spermine in the following aspects: 1) BESPM could stimulate globin and ornithine decarboxylase synthesis in a rabbit reticulocyte cell-free system; 2) the addition of BESPM to the culture medium could recover cell growth of polyamine-deficient bovine lymphocytes; 3) spermidine uptake by bovine lymphocytes was inhibited by BESPM and spermine to a comparable degree; and 4) stress-induced gastric ulceration was inhibited by subcutaneous administration of BESPM. Since BESPM was less toxic than spermine for mice, BESPM or its derivatives may be useful for diseases which can be cured by polyamines.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Ulcer Agents / pharmacology*
  • Cattle
  • Cell Division / drug effects*
  • Cells, Cultured
  • Gastric Juice / drug effects
  • Gastric Juice / metabolism
  • Globins / biosynthesis
  • Globins / genetics*
  • Lymphocytes / cytology*
  • Lymphocytes / drug effects
  • Lymphocytes / metabolism
  • Mice
  • Ornithine Decarboxylase / biosynthesis
  • Ornithine Decarboxylase / genetics*
  • Protein Biosynthesis*
  • Rabbits
  • Rats
  • Reticulocytes / metabolism
  • Spermine / analogs & derivatives*
  • Spermine / metabolism
  • Spermine / pharmacology*
  • Spermine / toxicity
  • Stomach Ulcer / prevention & control*
  • Stress, Psychological

Substances

  • Anti-Ulcer Agents
  • Spermine
  • N(1), N(12)-diethylspermine
  • Globins
  • Ornithine Decarboxylase