Abstract
PARACEST redox sensors containing the NAD(+)/NADH mimic N-methylquinolinium moiety as a redox-active functional group have been designed and synthesized. The Eu(3+) complex with two quinolinium moieties was nearly completely CEST-silent in the oxidized form but was "turned on" upon reduction with β-NADH. The CEST effect of the Eu(3+) complex containing only one quinolinium group was much less redox-responsive but showed an unexpected sensitivity to pH in the physiologically relevant pH range.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemistry*
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Europium / chemistry*
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Heterocyclic Compounds, 1-Ring / chemistry*
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Hydrogen-Ion Concentration
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Magnetic Resonance Imaging / methods*
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Organometallic Compounds / chemical synthesis
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Organometallic Compounds / chemistry*
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Oxidation-Reduction
Substances
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Amides
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Heterocyclic Compounds, 1-Ring
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Organometallic Compounds
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1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
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Europium