Abstract
We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses.
Publication types
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Child
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Female
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Humans
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Immunosuppression Therapy
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Incidence
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Influenza Vaccines / administration & dosage*
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Influenza Vaccines / adverse effects*
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Male
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Placebos / administration & dosage
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Respiratory Tract Infections / epidemiology*
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Respiratory Tract Infections / immunology
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Risk Assessment
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Vaccines, Inactivated / administration & dosage
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Vaccines, Inactivated / adverse effects
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Virus Diseases / epidemiology*
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Virus Diseases / immunology
Substances
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Influenza Vaccines
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Placebos
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Vaccines, Inactivated