Intravenous recombinant tissue plasminogen activator thrombolysis in acute ischemic stroke due to middle cerebral artery dissection

J Stroke Cerebrovasc Dis. 2012 Nov;21(8):915.e7-9. doi: 10.1016/j.jstrokecerebrovasdis.2012.02.003. Epub 2012 Mar 15.

Abstract

Beneficial effect of recombinant tissue plasminogen activator (rtPA) in cerebral arterial dissection is controversial. We experienced a 45-year-old man with acute ischemic stroke due to middle cerebral artery dissection, who was treated with rtPA. Characteristic vascular findings indicating dissection became evident only in subsequent angiographic examinations. Our case indicates that serial angiographic examinations should be essential after acute thrombolytic therapy, especially in young patients who are at a high risk of cerebral arterial dissection.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiography, Digital Subtraction
  • Aortic Dissection / complications
  • Aortic Dissection / diagnosis
  • Aortic Dissection / drug therapy*
  • Cerebral Angiography / methods
  • Fibrinolytic Agents / administration & dosage*
  • Humans
  • Infarction, Middle Cerebral Artery / diagnosis
  • Infarction, Middle Cerebral Artery / drug therapy*
  • Infarction, Middle Cerebral Artery / etiology
  • Infusions, Intravenous
  • Intracranial Aneurysm / complications
  • Intracranial Aneurysm / diagnosis
  • Intracranial Aneurysm / drug therapy*
  • Magnetic Resonance Angiography
  • Male
  • Middle Aged
  • Middle Cerebral Artery* / diagnostic imaging
  • Middle Cerebral Artery* / pathology
  • Recombinant Proteins / administration & dosage
  • Thrombolytic Therapy*
  • Tissue Plasminogen Activator / administration & dosage*
  • Treatment Outcome

Substances

  • Fibrinolytic Agents
  • Recombinant Proteins
  • Tissue Plasminogen Activator