Infarct size is regarded as the main factor determining short- and long-term prognosis after acute myocardial infarction. Effective reperfusion therapy reduces infarct size by half. Despite broad implementation of primary percutaneous coronary interventions, the prognosis in many patients with large infarcts remains serious. We present a case report on a patient with an anterior wall ST-segment elevation myocardial infarction successfully treated interventionally with the use of supersaturated oxygen delivery.