Thioglycine and L-thiovaline: biologically active H₂S-donors

Zongmin Zhou; Margarete von Wantoch Rekowski; Ciro Coletta; Csaba Szabo; Mariarosaria Bucci; Giuseppe Cirino; Stavros Topouzis; Andreas Papapetropoulos; Athanassios Giannis

doi:10.1016/j.bmc.2012.02.028

Thioglycine and L-thiovaline: biologically active H₂S-donors

Bioorg Med Chem. 2012 Apr 15;20(8):2675-8. doi: 10.1016/j.bmc.2012.02.028. Epub 2012 Feb 27.

Authors

Zongmin Zhou¹, Margarete von Wantoch Rekowski, Ciro Coletta, Csaba Szabo, Mariarosaria Bucci, Giuseppe Cirino, Stavros Topouzis, Andreas Papapetropoulos, Athanassios Giannis

Affiliation

¹ Department of Pharmacy, Laboratory of Molecular Pharmacology, University of Patras, Greece.

PMID: 22436388
DOI: 10.1016/j.bmc.2012.02.028

Abstract

Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H(2)S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H(2)S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H(2)S donors hold promise as novel treatments for cardiovascular diseases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / chemistry
Amino Acids / metabolism
Amino Acids / pharmacology*
Animals
Aorta / drug effects*
Aorta / metabolism
Cyclic GMP / biosynthesis
Cyclic GMP / metabolism
Glycine / analogs & derivatives*
Glycine / pharmacology*
Hydrogen Sulfide / chemistry
Hydrogen Sulfide / metabolism*
Mice
Myocytes, Smooth Muscle / cytology
Myocytes, Smooth Muscle / drug effects*
Myocytes, Smooth Muscle / metabolism
Rats
Valine / analogs & derivatives*
Valine / pharmacology*

Substances

Amino Acids
Cyclic GMP
Valine
Glycine
Hydrogen Sulfide