Abstract
We have recently developed new Tempo-PEG-RGDs conjugates and have quantitatively examined their antithrombotic and antioxidant capabilities. These compounds were therapeutically beneficial when characterized in both in vitro platelet aggregation assays and a rat model of arterial thrombosis. Moreover, these compounds demonstrated significant protection from organ damage in a rat model of ischemia/reperfusion. Our data indicate that Tempo-PEG-RGDs represent a new class of adjuvants with therapeutic efficacy in acute and transient ischemic damage.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Cyclic N-Oxides / pharmacology*
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Free Radical Scavengers / chemical synthesis*
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Free Radical Scavengers / pharmacology
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Hindlimb / blood supply
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Histocytochemistry
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Malondialdehyde / blood
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Muscle, Skeletal / physiopathology
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Oligopeptides / chemical synthesis*
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Oligopeptides / pharmacology
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Oxidative Stress / physiology*
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Platelet Aggregation / physiology
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Polyethylene Glycols / chemical synthesis*
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Polyethylene Glycols / pharmacology
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Rats
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Reperfusion Injury / blood
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Reperfusion Injury / drug therapy*
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Superoxide Dismutase / blood
Substances
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Cyclic N-Oxides
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Free Radical Scavengers
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Oligopeptides
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Polyethylene Glycols
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Malondialdehyde
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arginyl-glycyl-aspartic acid
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Superoxide Dismutase
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TEMPO