Abstract
A concise total synthesis of (±)-7-epi-nemorosone is reported. Our synthetic approach establishes a viable route to polycyclic polyprenylated acylphloroglucinol natural products (PPAP's) bearing a C-7 endo prenyl side chain. Key steps include retro-aldol-vinyl cerium addition to a hydroxy adamantane core scaffold and palladium-mediated deoxygenation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Benzophenones / chemical synthesis*
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Benzophenones / chemistry
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Biological Products / chemical synthesis*
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Biological Products / chemistry
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Cyclization
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Molecular Structure
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Stereoisomerism
Substances
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Benzophenones
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Biological Products
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nemorosone