Malaria vaccine development using synthetic peptides as a technical platform

Adv Immunol. 2012:114:107-49. doi: 10.1016/B978-0-12-396548-6.00005-6.

Abstract

The review covers the development of synthetic peptides as vaccine candidates for Plasmodium falciparum- and Plasmodium vivax-induced malaria from its beginning up to date and the concomitant progress of solid phase peptide synthesis (SPPS) that enables the production of long peptides in a routine fashion. The review also stresses the development of other complementary tools and actions in order to achieve the long sought goal of an efficacious malaria vaccine.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigens, Protozoan / immunology*
  • Humans
  • Malaria / immunology
  • Malaria / prevention & control
  • Malaria Vaccines / immunology*
  • Plasmodium falciparum / immunology
  • Plasmodium vivax / immunology
  • Protozoan Proteins / immunology*
  • Vaccines, Subunit / immunology*
  • Vaccines, Synthetic / immunology*

Substances

  • Antigens, Protozoan
  • Malaria Vaccines
  • Protozoan Proteins
  • Vaccines, Subunit
  • Vaccines, Synthetic
  • merozoite surface protein 3, Plasmodium