β-Peptoids: synthesis of a novel dimer having a fully extended conformation

Amino Acids. 2012 Nov;43(5):2005-14. doi: 10.1007/s00726-012-1275-1. Epub 2012 Mar 28.

Abstract

Chiral imines 1a,b, already synthesized in our laboratory, were converted in good yield by reduction into the corresponding N-benzyl-γ-lactams 2a,b. Desilylation followed by oxidation of the hydroxymethyl functionality gave the N-benzyl-β-amino acids 5a,b in good yield and high purity. Starting from compound 6a, the corresponding β-peptoid dimer 8 was prepared, together with its derivatives 9 and 10, these latter displaying conformational restriction about the peptide bond, as evidenced by NMR data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry*
  • Dimerization
  • Imines / chemistry*
  • Lactams / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Oxidation-Reduction
  • Peptoids / chemical synthesis*
  • Stereoisomerism

Substances

  • Amino Acids
  • Imines
  • Lactams
  • Peptoids