Troponin-positive chest pain with unobstructed coronary arteries: definitive differential diagnosis using cardiac MRI

Br J Radiol. 2012 Aug;85(1016):e461-6. doi: 10.1259/bjr/90663866. Epub 2012 Mar 28.

Abstract

Objective: The purpose of this study was to assess the outcome of cardiac MRI (CMRI) with late gadolinium enhancement (LGE) at outpatient follow-up in a consecutive series of patients with troponin-positive chest pain but unobstructed coronary arteries at the index admission.

Methods: The study group comprised 91 consecutive patients who presented to our institution with cardiac chest pain, elevated troponin I and unobstructed coronary arteries on coronary angiography. All patients underwent an outpatient CMRI with LGE imaging in order to establish a definitive diagnosis.

Results: The average time from coronary angiography to LGE-CMRI was 2 months. 73% of patients had no abnormality on their LGE-CMRI, 16% of patients had patchy late enhancement consistent with myocarditis and 11% had focal subendocardial or full thickness late enhancement consistent with myocardial infarction. There were no deaths in this cohort during a mean follow-up of 21 months.

Conclusion: LGE-CMRI is a useful tool for establishing whether such patients have definitive evidence of non-ST-segment elevation myocardial infarction (NSTEMI), and can make an important contribution to the long-term management strategy of these patients as an inappropriate diagnosis of NSTEMI carries important medical, social and financial implications.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Chest Pain / blood
  • Chest Pain / etiology*
  • Contrast Media
  • Coronary Angiography / methods
  • Coronary Vessels / anatomy & histology*
  • Diagnosis, Differential
  • Female
  • Gadolinium DTPA
  • Humans
  • Magnetic Resonance Angiography / methods*
  • Male
  • Middle Aged
  • Time Factors
  • Troponin I / blood*

Substances

  • Contrast Media
  • Troponin I
  • Gadolinium DTPA