PARP1 parylation promotes silent locus transmission in the nucleolus: the suspicion confirmed

Maxim Isabelle; Imed-Eddine Gallouzi; Guy G Poirier

doi:10.1016/j.molcel.2012.03.012

PARP1 parylation promotes silent locus transmission in the nucleolus: the suspicion confirmed

Mol Cell. 2012 Mar 30;45(6):706-7. doi: 10.1016/j.molcel.2012.03.012.

Authors

Maxim Isabelle¹, Imed-Eddine Gallouzi, Guy G Poirier

Affiliation

¹ Centre de recherche du CHUQ-Pavillon CHUL, Cancer Axis, Québec, Canada.

PMID: 22464439
DOI: 10.1016/j.molcel.2012.03.012

Abstract

Parylation modulates various processes, including transcription. In this issue of Molecular Cell, Guetg et al. (2012) show that, in the nucleolus, PARP1-mediated parylation of TIP5 promotes the silencing of rDNA chromatin during replication, uncovering the mechanism by which PARP1 ensures that silent rDNA regions are properly inherited.

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