Abstract
Angiogenesis is critical to the growth of human tumors and the development of metastasis. Amongst the many proangiogenic mechanisms identified, the vascular endothelial growth factor (VEGF) signaling pathway has been implicated as the key regulator of tumor neovascularisation. Various therapeutic agents targeting the VEGF pathway have been successfully developed, with many now approved and in routine clinical use. In general, VEGF-mediated angiogenesis can be inhibited by 2 approaches: antibodies directed against VEGF ligands or VEGF receptors (VEGFRs) and tyrosine kinase inhibitors targeting the VEGFRs. Thus far, clinical benefits achieved with VEGF-targeted agents are limited by their modest efficacy and the development of resistance. With no shortage of drugs in development, the lack of well-validated biomarkers to predict for response or resistance to VEGF-directed therapies is now becoming a key factor limiting the further rational development of this class of anticancer agent. This review discusses the biology of VEGF signaling, the clinical efficacy of VEGF-targeting therapies, potential mechanisms of resistance, and emerging predictive biomarkers.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Angiogenesis Inhibitors / administration & dosage
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Angiogenesis Inhibitors / therapeutic use*
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Animals
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Drug Resistance, Neoplasm / drug effects
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Drug Resistance, Neoplasm / genetics
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Humans
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Models, Biological
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Molecular Targeted Therapy / methods*
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Neoplasms / blood supply
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Neoplasms / drug therapy*
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Neoplasms / genetics
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Neovascularization, Pathologic / drug therapy*
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Neovascularization, Pathologic / genetics
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Neovascularization, Pathologic / metabolism
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Protein Kinase Inhibitors / administration & dosage
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Protein Kinase Inhibitors / therapeutic use
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Receptors, Vascular Endothelial Growth Factor / antagonists & inhibitors*
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Receptors, Vascular Endothelial Growth Factor / genetics
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Receptors, Vascular Endothelial Growth Factor / metabolism
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Receptors, Vascular Endothelial Growth Factor / physiology
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Signal Transduction / drug effects
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Signal Transduction / genetics
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Signal Transduction / physiology
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Vascular Endothelial Growth Factor A / antagonists & inhibitors*
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Vascular Endothelial Growth Factor A / genetics
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Vascular Endothelial Growth Factor A / metabolism
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Vascular Endothelial Growth Factor A / physiology
Substances
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Angiogenesis Inhibitors
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Protein Kinase Inhibitors
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Vascular Endothelial Growth Factor A
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Receptors, Vascular Endothelial Growth Factor