Abstract
We report 2 patients with Guillain-Barré syndrome (GBS) following Campylobacter jejuni enteritis. Electrophysiologic studies indicated that the predominant process was axonal degeneration of motor nerves, and clinical recovery was poor. Serum testing by thin-layer chromatography and enzyme-linked immunosorbent assay revealed that the sera from both patients contained high titers of IgG antibody against GM1 ganglioside. These cases may represent a subgroup of GBS as acute axonal polyneuropathy following C jejuni enteritis associated with anti-GM1 antibodies.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Autoantibodies / analysis*
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Campylobacter Infections / complications*
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Campylobacter jejuni*
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Enteritis / complications*
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Female
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G(M1) Ganglioside / immunology*
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Humans
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Immunoglobulin G / analysis
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Male
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Motor Neurons / physiology
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Neurons, Afferent / physiology
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Polyradiculoneuropathy / diagnosis
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Polyradiculoneuropathy / etiology
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Polyradiculoneuropathy / physiopathology*
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Sural Nerve / physiopathology
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Tibial Nerve / physiopathology
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Ulnar Nerve / physiopathology
Substances
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Autoantibodies
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Immunoglobulin G
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G(M1) Ganglioside