A new peptide isolated from a marine derived Streptomyces bacillaris

Nat Prod Commun. 2012 Feb;7(2):211-4.

Abstract

A new peptide, L-O-Lac-L-Val-D-O-Hiv-D-Val (1), consisting of D-valine, L-valine, L-lactic acid, and 3-D-hydroxyisovaleric acid, was isolated from the culture of the marine sediment derived Streptomyces bacillaris. The planar structure of compound 1 was assigned by 1D, 2D NMR and mass spectroscopic analyses. Following acid and base hydrolysis, the absolute configuration of the valine residues in 1 were determined by application of the advanced Marfey's method and the absolute configurations of hydroxy acids units were determined by a HPLC method based on Mosher's reagents.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / metabolism*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Oceans and Seas
  • Phylogeny
  • Protein Conformation
  • Streptomyces / chemistry
  • Streptomyces / classification
  • Streptomyces / genetics
  • Streptomyces / metabolism*

Substances

  • Bacterial Proteins