Chemistry and biology of acylfulvenes: sesquiterpene-derived antitumor agents

Chem Rev. 2012 Jun 13;112(6):3578-610. doi: 10.1021/cr2001367. Epub 2012 Apr 6.
No abstract available

Publication types

  • Review

MeSH terms

  • Alkylating Agents / chemistry
  • Alkylating Agents / pharmacology
  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / pharmacology*
  • Aziridines / chemistry
  • Clinical Trials as Topic
  • Cyclopropanes / chemistry
  • DNA Damage / drug effects
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Glutathione Reductase / antagonists & inhibitors
  • Humans
  • Mice
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / pharmacology
  • Spiro Compounds / chemistry*
  • Spiro Compounds / pharmacology*
  • Tissue Distribution
  • Xenograft Model Antitumor Assays

Substances

  • Alkylating Agents
  • Antineoplastic Agents
  • Aziridines
  • Cyclopropanes
  • Enzyme Inhibitors
  • Sesquiterpenes
  • Spiro Compounds
  • acylfulvene
  • aziridine
  • cyclopropane
  • Glutathione Reductase