Abstract
As the incidence of diabetes mellitus continues to rise, parallel increases in the rates of diabetic atherosclerotic vascular disease are projected to impart major health and socioeconomic challenges for authorities worldwide. Diabetes results in a proatherogenic phenotype, manifesting in an accelerated, diffuse, polyvascular fashion. In this review, we highlight the pathophysiological and morphological hallmarks of diabetic atherosclerosis.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Atherosclerosis / blood
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Atherosclerosis / etiology
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Atherosclerosis / pathology*
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Atherosclerosis / physiopathology*
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Calcinosis / physiopathology*
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Diabetes Mellitus, Type 2 / blood
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Diabetes Mellitus, Type 2 / complications*
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Diabetes Mellitus, Type 2 / pathology
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Diabetes Mellitus, Type 2 / physiopathology
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Diabetic Angiopathies / blood
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Diabetic Angiopathies / etiology
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Diabetic Angiopathies / pathology*
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Diabetic Angiopathies / physiopathology*
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Endothelium, Vascular / pathology*
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Endothelium, Vascular / physiopathology*
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Female
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Humans
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Insulin Resistance
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Male
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Oxidative Stress
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Reactive Oxygen Species