The ancient and evolving roles of cohesin in gene expression and DNA repair

Curr Biol. 2012 Apr 10;22(7):R240-50. doi: 10.1016/j.cub.2012.02.046.

Abstract

The cohesin complex, named for its key role in sister chromatid cohesion, also plays critical roles in gene regulation and DNA repair. It performs all three functions in single cell eukaryotes such as yeasts, and in higher organisms such as man. Minor disruption of cohesin function has significant consequences for human development, even in the absence of measurable effects on chromatid cohesion or chromosome segregation. Here we survey the roles of cohesin in gene regulation and DNA repair, and how these functions vary from yeast to man.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / metabolism*
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Cohesins
  • DNA Repair*
  • Eukaryota / growth & development
  • Eukaryota / metabolism
  • Gene Expression*
  • Humans
  • Sister Chromatid Exchange

Substances

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone