Axonally translated SMADs link up BDNF and retrograde BMP signaling

Neuron. 2012 Apr 12;74(1):3-5. doi: 10.1016/j.neuron.2012.03.012.

Abstract

Axonal target-derived BMP and neurotrophin signaling are both known to regulate neuronal gene expression, differentiation, and axon growth. In this issue of Neuron, Ji and Jaffrey (2012) discovered that BMP-signaling endosomes depend on BDNF-induced axonal synthesis of SMADs to retrogradely regulate transcription in developing trigeminal neurons, providing a mechanism of integrating the two target-derived signals.

Publication types

  • Comment

MeSH terms

  • Animals
  • Axonal Transport / physiology*
  • Axons / metabolism*
  • Cell Differentiation / physiology*
  • Smad Proteins, Receptor-Regulated / biosynthesis*
  • Smad1 Protein / biosynthesis*
  • Smad5 Protein / biosynthesis*
  • Smad8 Protein / biosynthesis*
  • Trigeminal Ganglion / metabolism*

Substances

  • Smad Proteins, Receptor-Regulated
  • Smad1 Protein
  • Smad5 Protein
  • Smad8 Protein