Investigation of the impact of HLA-DPB1 matching status in 10/10 HLA matched unrelated hematopoietic stem cell transplantation: results of a French single center study

Hum Immunol. 2012 Jul;73(7):711-4. doi: 10.1016/j.humimm.2012.03.013. Epub 2012 Apr 12.

Abstract

The impact of HLA-DPB1 mismatches after unrelated hematopoietic stem cell transplantation (HSCT) remains controversial. We retrospectively analyzed the impact of permissive/non-permissive HLA-DPB1 mismatches on the outcome of 141 patients who underwent 10/10 HLA allelic-matched unrelated HSCT. Each pair was classified according to the 3 (TCE3) and 4-group (TCE4) algorithm based on DPB1 alleles immunogenicity. Outcome analysis revealed that TCE3 and TCE4 non-permissive HLA-DPB1 disparities were not associated with worsened overall survival, relapse risk neither risk of acute GvHD. Overall, this single center retrospective study does not confirm the adverse prognostic of non-permissive HLA-DPB1 mismatches.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Alleles
  • Child
  • Child, Preschool
  • DNA Mutational Analysis
  • Female
  • France
  • Graft vs Host Disease / epidemiology*
  • Graft vs Host Disease / genetics
  • Graft vs Host Disease / mortality
  • HLA-DP beta-Chains / genetics
  • HLA-DP beta-Chains / immunology
  • HLA-DP beta-Chains / metabolism*
  • Hematologic Neoplasms / therapy*
  • Hematopoietic Stem Cell Transplantation*
  • Histocompatibility Testing
  • Humans
  • Incidence
  • Infant
  • Male
  • Middle Aged
  • Mutation / genetics
  • Retrospective Studies
  • Survival Analysis
  • Treatment Outcome
  • Young Adult

Substances

  • HLA-DP beta-Chains
  • HLA-DPB1 antigen