Use of a multicomponent reaction for chemoselective derivatization of multiple classes of metabolites

Kyle A Totaro; Babajide O Okandeji; Jason K Sello

doi:10.1002/cbic.201200035

Use of a multicomponent reaction for chemoselective derivatization of multiple classes of metabolites

Chembiochem. 2012 May 7;13(7):987-91. doi: 10.1002/cbic.201200035. Epub 2012 Apr 13.

Authors

Kyle A Totaro¹, Babajide O Okandeji, Jason K Sello

Affiliation

¹ Chemistry Department, Brown University, 324 Brook Street, Providence, RI 02914, USA.

PMID: 22505051
DOI: 10.1002/cbic.201200035

Abstract

We demonstrate that the Ugi reaction enables chemoselective derivatization of biological amines, carboxylic acids, aldehydes, or ketones with a chromophore under one set of reaction conditions, even in the presence of water. Derivatization of neurotransmitters, hormones, disease biomarkers and other metabolites bodes well for systems biology and diagnostic medicine.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Amino Acids / chemistry
Amino Acids / metabolism*
Biomarkers / chemistry*
Cyanides / chemistry
Cyanides / metabolism*
Metabolomics / methods*

Substances

Amino Acids
Biomarkers
Cyanides