Recognition of sialylated poly-N-acetyllactosamine chains on N- and O-linked glycans by human and avian influenza A virus hemagglutinins

Angew Chem Int Ed Engl. 2012 May 14;51(20):4860-3. doi: 10.1002/anie.201200596. Epub 2012 Apr 13.

Abstract

Human influenza viruses are proposed to recognize sialic acids (pink diamonds) on glycans extended with poly-LacNAc chains (LacNAc=(yellow circle+blue square)). N- and O-linked glycans were extended with different poly-LacNAc chains with α2-3- and α2-6-linked sialic acids recognized by human and avian influenza viruses, respectively. The specificity of recombinant hemagglutinins (receptors in green) was investigated by using glycan microarray technology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Birds
  • Carbohydrate Sequence
  • Hemagglutinins / chemistry
  • Hemagglutinins / metabolism*
  • Humans
  • Influenza A virus / chemistry
  • Influenza A virus / metabolism*
  • Influenza in Birds / virology*
  • Influenza, Human / virology*
  • Microarray Analysis
  • Molecular Sequence Data
  • Polysaccharides / chemistry
  • Polysaccharides / metabolism*
  • Sialic Acids / chemistry
  • Sialic Acids / metabolism*

Substances

  • Hemagglutinins
  • Polysaccharides
  • Sialic Acids
  • poly-N-acetyllactosamine