[Advances of DNA methylation in early diagnosis of lung cancer]

Zhongguo Fei Ai Za Zhi. 2012 Apr;15(4):234-41. doi: 10.3779/j.issn.1009-3419.2012.04.08.
[Article in Chinese]

Abstract

Lung cancer is the leading cause of cancer-related death and thus a major health problem nowadays. No early diagnostic method is ideal up to now. Changes in DNA methylation occur on early stage of lung cancer. Detection of DNA methylation is expected to be an important method in early diagosis of lung cancer.

肺癌是当今世界上对人类健康和生命威胁最大的恶性肿瘤,目前缺乏理想的早期诊断手段。在肺癌发生早期就存在很多DNA甲基化的改变,检测DNA甲基化有望成为肺癌早期诊断的重要手段。

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA Methylation*
  • Early Detection of Cancer
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / metabolism

Grants and funding

本研究受中瑞国际合作项目(No.09ZCZDSF04100)和国家"十一五"科技支撑计划项目(No.2006BAI02A01)资助