A new tumour suppressor enters the network of intestinal progenitor cell homeostasis

EMBO J. 2012 May 30;31(11):2444-5. doi: 10.1038/emboj.2012.115. Epub 2012 Apr 17.

Abstract

In this issue of The EMBO Journal, Wilson et al (2012) elegantly discovered an important new axis for intestinal homeostasis and cancer, using an RNAi screen to enhance the RAS-induced multivulva (MUV) phenotype in Caenorhabditis elegans.

Publication types

  • Comment

MeSH terms

  • Animals
  • Female
  • Homeostasis / physiology*
  • Humans
  • Intestines / physiology*
  • Intracellular Signaling Peptides and Proteins / physiology*
  • Male
  • Oxidoreductases
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Stem Cells / physiology*
  • Tumor Suppressor Proteins / genetics*
  • Vesicular Transport Proteins / physiology*

Substances

  • Intracellular Signaling Peptides and Proteins
  • NRBP1 protein, human
  • Receptors, Cytoplasmic and Nuclear
  • Tumor Suppressor Proteins
  • Vesicular Transport Proteins
  • Nrbf1 protein, mouse
  • Oxidoreductases