Abstract
Bacterial communities usually develop biofilms abound in nature niche. The development of biofilm is a highly dynamic and complex process coordinated by multiple mechanisms, of which two-component system and quorum sensing are two well-defined systems. Biofilm is involved in the virulence of many pathogens. Therefore, targeting the key factors involved in the biofilm formation represents a novel and promising avenue for developing better antibiotics.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acyl-Butyrolactones / metabolism*
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Bacteria / genetics
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Bacteria / metabolism*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Biofilms / growth & development*
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Drug Delivery Systems*
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Gene Expression Regulation, Bacterial
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Homoserine / analogs & derivatives
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Homoserine / metabolism
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Lactones / metabolism
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Quorum Sensing*
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Signal Transduction
Substances
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Acyl-Butyrolactones
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Bacterial Proteins
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Lactones
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N-octanoylhomoserine lactone
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Homoserine