Highly biocompatible, hollow coordination polymer nanoparticles as cisplatin carriers for efficient intracellular drug delivery

Hong-Yuan Lian; Ming Hu; Chia-Hung Liu; Yusuke Yamauchi; Kevin C-W Wu

doi:10.1039/c2cc31708g

Highly biocompatible, hollow coordination polymer nanoparticles as cisplatin carriers for efficient intracellular drug delivery

Chem Commun (Camb). 2012 May 25;48(42):5151-3. doi: 10.1039/c2cc31708g. Epub 2012 Apr 18.

Authors

Hong-Yuan Lian¹, Ming Hu, Chia-Hung Liu, Yusuke Yamauchi, Kevin C-W Wu

Affiliation

¹ Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.

PMID: 22514015
DOI: 10.1039/c2cc31708g

Abstract

Highly biocompatible coordination polymer (Prussian Blue) nanoparticles (LC(50) > 1000 μg mL(-1)) with a hollow interior and a microporous framework (denoted as HPB) are utilized as an anticancer drug (i.e. cisplatin) capsule for chemotherapy of bladder cancer T24 cells.

MeSH terms

Antineoplastic Agents / toxicity
Apoptosis / drug effects
Biocompatible Materials / chemistry
Cell Line, Tumor
Cisplatin / toxicity
Drug Carriers / chemistry*
Ferrocyanides / chemistry
Humans
Nanoparticles / chemistry*
Polymers / chemistry*
Urinary Bladder Neoplasms / pathology

Substances

Antineoplastic Agents
Biocompatible Materials
Drug Carriers
Ferrocyanides
Polymers
Cisplatin
ferric ferrocyanide