Late gadolinium enhancement as a potential marker of increased perioperative risk in aortic valve replacement

Interact Cardiovasc Thorac Surg. 2012 Jul;15(1):45-50. doi: 10.1093/icvts/ivs098. Epub 2012 Apr 17.

Abstract

OBJECTIVES Risk assessment of patients with aortic stenosis (AS) undergoing aortic valve replacement (AVR) is challenging. We set out to determine the impact of myocardial late gadolinium enhancement (LGE), as detected by cardiovascular magnetic resonance (CMR), on postoperative outcomes following AVR. METHODS A prospective observational study was conducted on patients undergoing CMR using the LGE technique within 1 year of subsequent AVR. Patients were categorized into absent, mid-wall or infarct patterns of LGE by independent observers blinded to all clinical data, and data were collected with regard to 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE) and postoperative complications. RESULTS A total of 63 patients were studied. Twenty-five patients had no LGE; 20 had mid-wall LGE and 18 had an infarct pattern. The incidence of MACCE, cerebrovascular accident (CVA) and heart block were significantly higher in the mid-wall group compared with the other two groups (MACCE: 25 vs. 0 vs. 5%, P = 0.014; CVA: 20 vs. 0 vs. 0%, P = 0.013; heart block: 30 vs. 4 vs. 12%, P = 0.050). Patients with no LGE had no 30-day MACCE events and no deaths up to 2 years of follow-up. CONCLUSIONS The myocardial LGE holds promise as a means of predicting risk prior to AVR for AS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Aortic Valve Stenosis / complications
  • Aortic Valve Stenosis / diagnosis*
  • Aortic Valve Stenosis / mortality
  • Aortic Valve Stenosis / pathology
  • Aortic Valve Stenosis / surgery*
  • Cerebrovascular Disorders / etiology
  • Chi-Square Distribution
  • Contrast Media*
  • Female
  • Fibrosis
  • Gadolinium DTPA*
  • Heart Block / etiology
  • Heart Valve Prosthesis Implantation / adverse effects*
  • Heart Valve Prosthesis Implantation / mortality
  • Humans
  • London
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Myocardial Infarction / complications
  • Myocardial Infarction / diagnosis*
  • Myocardial Infarction / mortality
  • Myocardial Infarction / pathology
  • Myocardium / pathology*
  • Predictive Value of Tests
  • Prospective Studies
  • Risk Assessment
  • Risk Factors
  • Treatment Outcome

Substances

  • Contrast Media
  • Gadolinium DTPA