Versatile synthetic strategies for PBCA-based hybrid fluorescent microbubbles and their potential theranostic applications to cell labelling and imaging

Chem Commun (Camb). 2012 May 25;48(42):5142-4. doi: 10.1039/c2cc18048k. Epub 2012 Apr 19.

Abstract

This research reports the versatile synthetic strategies for hybrid PBCA microbubbles as contrast agents and drug carriers loaded with fluorescent dyes and magnetic nanoparticles serving in vitro cell labelling and in vivo target imaging. These multifunctional probes therefore prove their potential biomedical applications in cancer diagnostics and treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Contrast Media / chemistry
  • Cyanoacrylates / chemistry*
  • Drug Carriers / chemistry
  • Enbucrilate
  • Fluorescent Dyes / chemistry*
  • Humans
  • Magnetic Resonance Imaging
  • Magnetite Nanoparticles / chemistry
  • Mice
  • Mice, Nude
  • Microbubbles*
  • Microscopy, Confocal
  • Neoplasms / pathology
  • Vascular Endothelial Growth Factor Receptor-2 / metabolism

Substances

  • Contrast Media
  • Cyanoacrylates
  • Drug Carriers
  • Fluorescent Dyes
  • Magnetite Nanoparticles
  • Vascular Endothelial Growth Factor Receptor-2
  • Enbucrilate