Abstract
T-bet is a transcription factor that drives the Th1 immune response primarily through promoting expression of the IFN-γ gene. Polymorphisms in the T-bet gene, TBX21, have been associated with immune-mediated diseases such as asthma and systemic sclerosis. We found that the TBX21 promoter polymorphism T-1993C is associated with a significant decrease in IL-4 and IFN-γ production by stimulated primary human lymphocytes from healthy participants.
Copyright © 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
Female
-
Gene Expression Regulation / immunology
-
Genetic Association Studies
-
Humans
-
Interferon-gamma / biosynthesis*
-
Interferon-gamma / immunology
-
Interleukin-4 / biosynthesis*
-
Interleukin-4 / immunology
-
Lymphocyte Activation / drug effects
-
Lymphocytes / drug effects
-
Lymphocytes / immunology*
-
Male
-
Middle Aged
-
Polymorphism, Single Nucleotide*
-
Primary Cell Culture
-
Promoter Regions, Genetic / immunology
-
T-Box Domain Proteins / genetics*
-
T-Box Domain Proteins / immunology
-
Tetradecanoylphorbol Acetate / pharmacology
Substances
-
T-Box Domain Proteins
-
T-box transcription factor TBX21
-
Interleukin-4
-
Interferon-gamma
-
Tetradecanoylphorbol Acetate