SIGIRR, a negative regulator of colon tumorigenesis

Drug Discov Today Dis Mech. 2011 Winter;8(3-4):e63-e69. doi: 10.1016/j.ddmec.2012.02.003. Epub 2012 Mar 15.

Abstract

Inappropriate activation of the Toll-IL-1R (TL-IL-1) signaling by commensal bacteria contributes to the pathogenesis of inflammatory bowel diseases and colitis-associated cancer. Recent studies have identified SIGIRR as a negative regulator of TL-IL-1 signaling. It dampens intestinal inflammation and tumorigenesis in the colon. In this review, we will discuss the role of SIGIRR in different cell types and the mechanisms underlying its tumor suppressor function.