Abstract
Radiofluorinated 4-fluorobenzonitrile oxide and N-hydroxy-4-fluorobenzimidoyl chloride rapidly react with different alkenes and alkynes under mild conditions. These cycloadditions are suitable for the preparation of low-molecular weight radiopharmaceuticals and, in a strain-promoted variant, can enable easy labelling of sensitive biopolymers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemistry*
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Azides / chemistry*
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Click Chemistry
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Cyclization
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Fluorine Radioisotopes / chemistry*
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Nitriles / chemistry*
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Oxides / chemistry*
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Radiopharmaceuticals / chemical synthesis*
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Radiopharmaceuticals / chemistry
Substances
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Alkynes
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Azides
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Fluorine Radioisotopes
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Nitriles
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Oxides
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Radiopharmaceuticals