Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer

Cancer Res. 1990 Dec 1;50(23):7710-6.

Abstract

Parathyroid hormone-related protein (PTHrP) is known to be a causative factor in humoral hypercalcemia of malignancy. A polyclonal rabbit antiserum directed against the amino-terminal region of the protein and immunoperoxidase methods have been used to locate the presence of PTHrP in a series of 102 consecutive invasive breast tumors removed surgically from normocalcemic women. Positive PTHrP staining was detected in 60% of the tumors but not in the accompanying normal breast tissue. Positive staining was related to the progesterone receptor status of the tumor (P = 0.039) and to the prognostic index of the patient (P = 0.046) and not to estrogen receptor status, patient age, tumor size, histological grade, or nodal status.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Neoplasm Proteins / biosynthesis*
  • Neoplasm Staging
  • Parathyroid Hormone-Related Protein
  • Prognosis
  • Protein Biosynthesis*
  • Receptors, Estrogen / analysis
  • Receptors, Progesterone / analysis

Substances

  • Neoplasm Proteins
  • PTHLH protein, human
  • Parathyroid Hormone-Related Protein
  • Receptors, Estrogen
  • Receptors, Progesterone